Scientists at GM's global research department have created a new technology that allows researchers to observe cancer cells in greater detail. The system, called MultiOmyx, allows experts in cancer research and treatment to analyze dozens of proteins on a single tissue slice. This technology allows experts to get more information from a single sample, and can become an effective tool for pathologists to understand cancer faster and more.
This is a standard stained tissue slice sample. It is called the H&E sample and is used by pathologists for basic cancer diagnosis. This particular sample was derived from lung tissue with cancer. This sample has not yet been labeled as a disease, but pathologists can still identify cancer features in tissues by observing the shape and arrangement of cells. If you look carefully, each nucleus is dark purple, the mass of malignant tumors is pale pink, and the red blood cells in blood vessels are bright pink.
With GE's new technology, you can see the cancerous cells more clearly. Malignant tumors show red cells and blue nuclei.
But researchers need to study non-cancer cells more carefully, because these immune cells may be the key to fighting cancer. You can see that researchers identify healthy cells in samples by blue and pink coloring. Healthy cells include light blue T cells and pink macrophages.
The green ones are fibroblasts, which have been shown to stimulate the growth of cancer cells. White and yellow stains indicate that blood vessels pass through the tumors.
To better understand the function of cancer cells, researchers removed common cancer cell spots and fibroblast spots. Red regions represent potential drug targets. By studying cells in this way, pathologists can better understand what drugs are more effective in treating different types of cancer.
This is another patient's lung tissue sample, which is more serious than the first sample. Researchers have used red, green and blue colors to label proteins that may be targets of drug treatment.
In the third lung tissue, cancer stem cells were blue-green. Recognition of stem cells is very important for researchers because they are highly resistant to chemotherapies. By observing how many stem cells exist, researchers can better assess how effective they are.
This is the breast tissue cell, and the MultiOmyx system is used to show the precursor cells of breast cancer. Two proteins, pink and light blue, are usually not found in healthy breast tissue.
The purple and gold regions on the left are more than two breast cancer-related proteins. But there are also quite powerful immune cells on the right side. These immune cells are red, green and blue. A large number of immune cells may mean that the body is trying to fight these new tumors.
This is a tissue sample of prostate cancer observed under the Multiomyx system. Cancer cells are purple, while non-cancerous tissue is golden.